Before that, I could not touch-type on QWERTY, but learned the Neo layout a couple of years back. I gave up on it because I was using too many other machines then. It felt more natural, but I think what really makes the difference for me is the keyboard. On the Kinesis, it is very obvious which finger to use for each key. I was a lot more confident in the physical mapping within days than after decades on standard staggered layouts. I wish there were ortholinear options for laptops.
The first 2 months was stressful, after that it was fine. I think it probably took a year to get back to the same level as I was at with Qwerty though in terms of speed (I was pretty fast), but I only did typing tutors for that first 2.5 weeks, so I probably could have improved things by using them more.
I actually switched back from an ergonomic keyboard to my MacBook Pro keyboard as I no longer needed the ergonomic layout and I could type faster on the MacBook. Had brief RSI symptoms for an hour once since switching to Dvorak, vs a few hours every few weeks on Qwerty. I imagine I'll end up back on an ergonomic keyboard eventually, but between that and Dvorak I think I'm set for my career.
Edit: you can learn the basics with typing games in a few days but then you commit and switch to it full time and your WPM drops to like 10. It takes a while to build up the muscle memory again and it's a tough experience. Like learning to walk again.
Mind you, I never claimed to be a particularly fast typist on any layout, although I have been touch typing for several decades, and on that note I am just as productive on Dvorak as on qwerty -- but at far lesser expense. That is to say, don't switch for the (mythical?) increased typing speed, switch for the ~30%(!) reduction in finger movement and pleasant "rolling" motions you gain.
True, it's not easy to share computers, be it you using somebody else's machine or somebody else using your machine. The latter can easily be addressed by quick layout changes (again, a pain to get right on Windows but a breeze on Linux), while I find that the former doesn't really bother me so much -- curiously, when I can't touch type (such as on my phone), I am hopelessly slow on Dvorak but quite efficient hunting-and-pecking on qwerty (possibly because I retain training from before touch typing?). The most glaring downside is the situations where keys and shortcuts are clearly laid out for qwerty and won't allow you to remap them (case in point: WASD in games); in reality most shortcuts are easy enough to use regardless of layout (side note: I've always been using Ctrl/Shift+Insert/Delete for cut/copy/paste, so the locations of X, C, and V don't affect me -- but modern keyboards with misplaced or missing Insert keys do).
To answer you question: I very specifically switched during the week before New Year's eve, when I could be reasonably sure that things at the office were slow enough to allow me to struggle through an unaccustomed layout. Honestly, the first days were atrocious, but within a week (so ~35 hrs) I had internalized the layout to a reasonable degree, and within a very few weeks (3? I don't really remember) I was up to my usual typing speed.
Bonus: here, have a go and try for yourself: http://gigliwood.com/abcd/lessons/ (no affiliation)
* Specifically, the Norwegian variant of Dvorak, because I need some localized keys. This has been a challenge, but a surmountable one, back on Windows (along with changing the keyboard layout for the Windows login screen, which truly defined the pinnacle of obscurity) -- on Linux it is dead simple to set up and just works.