I don't have a degree and I've never had a problem, I've worked in Healthcare, for startups and for a publicly traded company. The biggest issue I've had was on a personal level, whenever I interview I'm anxious that others won't view me the same without a degree.

I signed up for the newsletter to this site, I like the idea of companies flat out saying a degree isn't required - otherwise I feel like I'm being judged negatively for not having one.