I don't think I'm understanding your question, and maybe I haven't laid down the situation fully.

My company is a Windows shop, and nearly everyone who isn't a developer (so nearly my entire internal customer base) does not have Python installed.

I want to be able to send over single file executables that have everything they need. I don't want to have to think about using pip, or distributing wheels, or making sure they have internet access, or if they have admin or not. And as internal tools, I can afford to deal with relatively large file sizes.

For example, I have a lot of tools that need numpy and scipy to accomplish their goals.

That all said, Gooey + PyInstaller typically does a good job at solving my problems.