A large portion of the web uses this plugin. If the site doesn't work with it I would consider that broken. Additionally UBO should not cause basic site layout to break unless something is wrong on the sites side (like including formatting markup from an advertising domain).

Thanks for stating the obvious though. Nevermind the other comments saying the exact same thing about the site being broken for them too. Just trying to help not have the site be broken for a portion of visitors.

The layout works? On mine with UBO running everything gets bunched up on the left side.