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So, there may be a real, meaningful question which result is 42, when using a different "base" to view the question at?

I think it's more poetic to view it as the question for the meaning of everything has a wrong answer to it.

It doesn't make sense, the universe isn't specifically obligated to make any sense, so why should the ultimate question and answer?

'I may be a sorry case, but I don't write jokes in base 13.' - Douglas Adams

By coincidence mostly.

Are you saying the improbability of that approaches infinity?