Javascript has become mostly a lost cause as far as open source development goes, as it's basically owned and controlled by NPM Inc and corporate interests now, but WebAssembly at least still has the possibility of remaining open.
At the very least, we should go through a period of experimentation by the community to settle on the best possible solutions (or sets of solution) and let things mature a bit, first. Now is not the time to bless a single runtime, package manager, etc.