Specifically, I think that there exists a lisp with a set of axioms that split program execution into "compile-time" execution (facts known about the program that are invariant to input) and a second "runtime" execution pass (facts that depend on dynamic input).
For example, multiplying a 2d array that's defined to be MxN by an array that's defined to be NxO should yield a type that's known to be MxO (even if the values of the array are not yet known). Or if the first parameter is known to be an upper-triangular matrix, then we can optimize the multiplication operation by culling the multiplication AST at "compile-time". This compile-time optimized AST could then be lowered to machine code and executed by inputting "runtime" known facts.
I think that this is what's needed to create the most optimally efficient "compiled" language. Type systems in e.g. Haskell and Rust help with optimization when spitting out machine code, but they're often incomplete (e.g., we know more at compile time than what's often captured in the type system).
I've put "compilation" in quotes, because compilation here just means program execution with run-time invariant values in order to build an AST that can then be executed with run-time dependent values. Is anyone aware of a language that takes this approach?