With .NET Core 3, you can deploy them standalone, and performance is much improved. So you might have a happy middle ground available now.

And when I say performance is improved, there are two fronts to that. First, the compiler/jit are just better now, core library functions are sped up a ton, so just running ported old .NET Framework code will be a lot faster. But also, C# has added new features in recent years that give you further control over memory usage/layout, and now even SIMD Intrinsics, so the performance ceiling is much higher if you want to optimize your own code.