I've only done mushrooms once, and I've never wanted a cigarette more in my life than during that experience.
IME mushrooms cause any low-consciousness activities like smoking/drinking/mindless partying to seem repulsive.
Edit for one more thought on this: it also gave me an appreciation for vegans and vegetarians. I was eating chicken while tripping once and really had some inner conflict over if it was ok to eat another animal. I'll never be a vegetarian, but for a brief moment I understood what all my hippie friends are on about :)