For example in "The Problem of Induction" you can see a bajillion sunrises but can't infer that there will be another. Likewise you can conduct a bajillion controlled experiments and can't really tell if the result will generalize. Worse yet is that the more conditions you control, the less likely it's to generalize. Infamously, clinical trials wanted to control for the variations caused by periods so they only tested on men and it turns out some drugs affect women differently! In general, if you control for everything, you can't say anything about the real world outside of those precise lab controlled conditions.