I came to the opposite conclusion. When you add perspective to game visualizations, it becomes harder to judge distances, estimate angles, make out details, and identify borders. Small items tend to get reduced to squint-inducing shapes. Large items occlude each other and cause an infuriating visibility problem. The only advantage is that it looks a little bit more like a "real" world, but if you're using a simplified art style, it doesn't matter anyway.

From a UX standpoint, the best balance is "iconic" perspective - most things rendered flat with low occlusion, like an Egyptian painting, much of medieval art, or Japanese woodblock prints. All the boundaries can remain clearly delineated with this style, but aesthetics can be retained through careful composition of each icon.

I did exactly this style for the game I'm working on. My reference points(within video games) are Ultima 1-5, Heroes of Might and Magic, and Battle for Wesnoth. In these games you are never wondering what something is, because you can always make out what it looks like.