Interesting because I'm using it mostly as a windowing/tiling use case. I liked it better than using multiple windows/frames in say Emacs, and I didn't like learning new window/pane splits using iTerm2 (OS X).

But you're super right, I have so many little "quirky" things that just don't work right, like I used to be able to easily double click a line and it would just copy it to a buffer; pasting from my host OS requires different key bindings, and my TMUX config file has slowly grown as I tried to get it working just right... Might be time for me to learn iTerm2 properly....(maybe I can modify keyboard shortcuts to be like Tmux for moving around to different panes....) But part of me worries about the time when I have to go back to a remote dev env where I'm expected to SSH to a protected source code machine.