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Comment by nighthawk648 | Hacker News Reader

What’s your background?

It seems the answers to these questions are either intuitive or irrelevant.

> - how is the fluid itself cleaned?

See the intuitive and imaginative answer would say something along the lines of white blood cells would consume the toxins.

How is bacteria during an infection cleaned? White blood cells consume them!

Why would this point even add to your discourse? It has no relevance. Either the fluid gets cleaned or it doesn’t. Either way there is a correlation between brain health and the fluid.

Also it’s not like a fucking snow globe. Or mouth wash. It’s not just a fluid reused and swashed back and forth.

Again, this is why I’m asking what your background is. Did you even read the article?

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I read the article, it talks about the brain as if it's a washing machine, which it's not either.

Why would it not be relevant? While there are white blood cells in CSF, it's several orders of magnitude less than in blood. Is it enough to clean anything? White blood cells don't pass the brain-blood barrier. So yeah, it's somewhat like a snow-globe for a lot of molecules and cells.

So yeah, how is the fluid cleared?

Also article states, that there's even less blood flow during the sleep cycle, so at the same time, there's even less opportunity to wash away things that can pass through blood-brain barrier away to the kidneys and out.

My background is watching a lot of biology and trying to understand.

> my background is watching a lot of biology and trying to understand.

I think while it is okay to ask questions and to be curious you should be careful of imply or imparting logical fallacy and making judgment on such fallacy.

Do some research and try to understand more about the CSF and the cleaning process. There are articles out there.

Again the research shows correlation, while correlation does not imply causation until you can falsify the hypothesis you should be careful creating bias. Maybe the mere act of the fluid passing around in the brain is enough to dilute and weaken the toxin bonds, which then dilutes the effect over certain areas of the brain.

Alzheimer research is very limited, and any insight into the potential cause and effect is important to give funding to. Dissent like the one you are trying to create only harms society.

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