My favorite sex-affecting genetic incident is Androgen insensitivity syndrome [1]. People with Y chromosome who have complete androgen insensitivity syndrome [2] have fully female external bodily features; their reproductive systems are ill-developed, and they are infertile.
> Most individuals with CAIS are raised as females. They are born phenotypically female and usually have a heterosexual female gender identity; However, at least two case studies have reported male gender identity in individuals with CAIS. [2]
[1] https://en.wikipedia.org/wiki/Androgen_insensitivity_syndrom...
[2] https://en.wikipedia.org/wiki/Complete_androgen_insensitivit...
I'm contemplating a sex reassignment therapy method by provoking CAIS using CRISPR gene editing...