The other upside to sealing plus mechanical ventilation (instead of leaky-building ventilation) is that your building is always fresh. Leak-driven ventilation leads to a building that is drafty on windy days and stuffy on calm days.
If it is, the whatever dust that gets picked up ends up in filters in the first week of operation.
both. That is it varies between different units but also varies with local conditions, if your local conditions are "heavy-duty" (very high humidity, smog, area with lots of dust or lots of pollens etc.) you should consider replacing more frequently than rated intervals.