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Skitch (http://skitch.com/) is my favorite Mac app in terms of usability. Of course, I need simple screen capture software (not everybody does).

I prefer CloudApp (http://getcloudapp.com). There's almost no UI it at all: it just captures OS X screenshots and uploads them.

I gave Skitch three minutes and gave up. Its UI is far too complicated for what it does.

Less simple than Shift-Command-3/4?