What game and what advantage? It's a Q/A site. The only way you are going to game the system is if you ask clearly delineated questions and provide thoughtful and clear answers.
Form a cabal of vote sharers, who always vote for each other's posts. Post a bunch of semi-plausible content once a day and you'll have tons of karma in no time.
Post quick responses that have little insight. You'll always get votes for being first.
Post LOTS of trivial questions. More people will upvote than will downvote on the whole.