Dunno, but all kinds of things could happen with novel co-dependent alleles with devistating effects when the express. Imagine theres a cool gene edit in 100 years that lets you live to 200 easy and it becomes normal for most people to get it. But, it just so happens that thers an early gene edit that was available 20 years from now, less ethically created and expensive. but hundreds of thousands of people get that first life extender.

Then, turns out the better / safer one 70 years from now has a co-expression with the decendents of the people who got it 20 years from now that makes you infertile, senile, or whatever.

thats the danger. If these edits become available broadly, youre not only worrying about co-expressions of edit genes developed at the same time, but edit genes developed at any time in the past (oh and also the rest of the human genome, which we still dont understand fully, and is a base concern for any gene editing whatsoever)