Lucasfilm? Pixar? EA? It's not exactly hard to spot the impact on pop culture.
I always thought Pixar was close to Oakland, not SF. Lucasfilm is a pretty good pick. But there are a lot of other higher impact studios in SoCal.
EA's talent is spread all over the globe. What games are developed in SF? I don't see how a corp HQ that mostly buys studios after they make a breakout game as a center of culture (center of power, yes. culture, no)