For any life-critical system you want first and foremost to have a battery of end-to-end tests that run the software on the target hardware under various operating conditions. No amount of software-only testing/formal methods will give you this part.
Then, you want to have a formal specification of your program that can be run through a model checker - this would be the industry standard, though, if you have a team of PhDs at your disposal, you could also try to go with full formal verification a la Coq.
Finally, you want unit testing, integration testing, and possibly a type system to help day-to-day development. But do note, none of these should be critical for assuring the system works as indended - if typos in your code aren't caught by your end-to-end tests, what hope is there that they will catch complex dynamic behaviors?