A) It's extremely general or even "foundational" in the sense that it's asking whether any algorithm at all exists to solve an extremely general sort of problem in polynomial time.
B) All of the standard methods used to solve problems of this sort have at least been pronounced exhausted at this point.
C) Very few theorems that inherently limit the speed of a class of problems actually have ever been proven. Very few methods for proving these constraints are known.
D) A lot of famous theorems have yielded results through being embedded in a larger, different field where they are just one result of many proved with a new machinery (Fermet most prominently). But given P=!NP is so general it can't really embedded in a larger, tractible space - lots of things are equivalent to it but all these things are kind of the same.