I do not know much about commercial real estate but why would big chains pay top dollar? McDonalds is famous for seeking bargains on real estate and here in dowtown Toronto Starbucks did not flinch to axe several underperforming locations.
Another somewhat related problem that I know happens in NYC is a building is owned by a parent who dies and leaves the property into split ownership amongst the children. Then the children cannot agree on a strategy to rent the building. And the fight results in an empty property.