Interesting article. While I definitely think you should be profiling your code to figure out the hot spots, cProfile has some limitations for profiling: cProfile doesn't give you line numbers, doesn’t work with threads, and significantly slows your program down.

I wrote a tool py-spy (https://github.com/benfred/py-spy) that is worth checking out if you’re interesting in profiling python programs. Not only does it solve those problems with cProfile - py-spy also lets you generate a flamegraph, profile running programs in production, works with multiprocess python applications, can profile native python extensions etc.