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What is the theory here with MR1? They say it’s a metabolic indicator, but it’s a MHC. Looks to be involved with B3/NAD. Does a cancer cell just run out of NAD so MR1 doesn’t get presented?

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Side note: I’ve been self-experimenting with high doses of niacinamide, and experiencing some weird side effects, possibly immune-related, like angular chelitis. Probably unrelated.

Please tell us more.

High dose of NMN are supposed to be helping develop some cancers.

angular chelitis is totally new to me. Are you on retinoids by any chance?

I took a lot of cod liver oil once it started, maybe a little bit before too, so I suppose it could be that. I did a lot of research into what would increase NAD levels, and it’s all pretty inconclusive, so I figured niacinamide was as good as any other B3 in the pathway. I later found that it chelates with some minerals, so I may be giving myself a deficiency.

Yes a deficiency is far more likely than an autoimmune disorder

Might be inhibiting sirtuin activity... http://www.jbc.org/content/277/47/45099.short

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