I've been working on a rather ambitious piece of software and I'm definitely worried that I'll get sued into oblivion over some minor user interface feature before I ever really make any money off it. I've lived all my life in the U.S. but would entertain the idea of leaving.
In fact if I'm going to leave my home town I feel like I might as well go someplace more exotic than Silicon Valley or New York. IP laws and other business concerns would definitely be an important criteria if I got serious about it.