Im sorry but why would someone want to use a templating language to configure infrastructure? It’s like using CSS syntax for defining an HTTP API. Doable, but... why? It’s not any easier to pick up or reason about than any existing configuration language.
On React + node, this assumes no rendering on the server, plus you’ll need to pick your own state management solution, data layer, http framework, router, and a whole host of secondary tools, which will comprise about 96% of your actual development time.