No. Listen to the Talking Machines podcast with Nick Patterson (who was a senior VP in research at RennTech for a long time). To paraphrase he says that the vast majority of their strategies are no more than simple linear regression. The challenge is that even though regression is conceptually simple it still takes smart people to answer questions like "what should you be regressing", or "should you apply any transform" or "how should you clean your data" or "do you understand the process well enough to realize when results are obviously unrealistic".
The thing that makes a firm like Renaissance a league above a firm like Two Sigma is the same thing that makes Two Sigma a league above a firm like Winton. It's not mathematical gnosticism, it's plain old operational excellence. It's things like expansive reliable curated datasets, deep expertise on market structure, good execution systems, powerful research and backtesting software, good access to markets, economies of scale, talented practitioners, and excellent organizational management.