Interesting article. Any new emotion or new emotional state creates a new space for new memories, and adolescence provides new emotions. Particular memories are easier to retrieve when in the emotional state they were formed. Maybe this explains why it can be hard to beat depression - pleasant memories are more difficult to retrieve and negative emotions easily surface.

First few times trying weed it felt like micro-tarzan swinging from a familiar branch of neurons to a whole new area of neurons.

Possibly why magic mushrooms and the like are being investigated as a legit therapy.