Also, consider that "keep ~100% of my net worth invested in these main problems" may not be the better strategy for funding those problems, versus "put net worth in growth investments" that can fund the same problems later on.
I don't believe in profiting from life-saving medication or anything like that, so my intention is to drive rapid growth with my activities in the energy, software, and automotive sectors to fund the less immediately profitable goals.
Make money solving the problems I can first, and later use that money to fund the further-off ones.
Currently this strategy is working well, as my assets are growing at above 2000% annually.