Sendy has abysmal performance for large lists though.
The real problems come when you try to use the SMTP gateway. It's quite slow and unreliable and doesn't really work for parallel workloads. The only way to somewhat mitigate it is to deploy a postfix into EC2 and then queue your emails there.
Ah, that's helpful to know. I would normally have wanted to use the SMTP gateway as a more portable API, to avoid tying things to Amazon-specific APIs. But it sounds like doing so would add substantial fragility.