I'm not really convinced by this type of reasoning. Things do matter if people care very deeply about them. If someone murdered someone close to you (to take an extreme example), would you still say that that is fine, because in the grand scheme nothing matters? You might say that you're an irrational human being, and that's why you care. But why should we take a definition of "meaningful" that is so disjoint for everyday human experience?
What would a hypothetical world look like in which life does have meaning, according to your definition? If no such world is even imaginable, then it isn't even clear what we are talking about.
Furthermore, I think some people use the supposed "meaninglessness" of life to justify passivity. If the universe is truly meaningless, then doing nothing is as meaningful as doing something traditionally considered meaningful.
Yet, people often base their behavior on their current emotional state. That is not the behavior of someone who believes in the complete meaninglessness of everything. Clearly, that person believes that his emotions matter and are a good guide to choose which actions to take. Playing Xbox on the couch or ruminating about the meaninglessness of life being good examples of this. Such actions are choices that are ultimately derived from value judgments.