> One of the reasons for the elegant appearance of the aircraft was the fuselage shape, a continuously variable profile with no two bulkheads the same shape. This construction was expensive and was replaced by mostly tube-shaped modern airliners. The tube is more resistant to pressurization changes and cheaper to build.
With blended wing bodies, you would again need a continuously variable profile for the whole fuselage (rather than only the wing, as in modern "tube-and-wing" planes). To build a larger or smaller variant, you would have to redesign the whole fuselage, rather than just adding/removing a few tube segments. So, even with updated tools, there will still be a lot of challenges...