Ergonomically.. well it's hard to describe TBH, the easiest way to see is to just download one of these systems and try using them. You try to prove a theorem and everything just ends up taking way longer than you'd expect. Mostly because you can't gloss over small details the way mathematicians will do informally. Every small turn of phrase like "for large enough N" or "without loss of generality" can become dozens of extra lines of code.