I started with Quad9 (9.9.9.9) and Cloudflare as a backup (1.1.1.1).
One thing I noticed right away was that my ping times to Cloudflare ended up being way faster (15ms) compared to Quad9 (50ms). Cloudflare seems to have a presence in my local area.
Now both are good, but adding a 50ms delay (+TCP handshake + TLS setup and teardown) seemed like a non-trivial amount. I ended up putting Cloudflare first.
There was a noticeable difference, something to think about if you decide to set this up.