I think part of the problem with an approach like this is it seems sweetness itself triggers a whole path of biochemical processes that are unhelpful [1].
[1] https://www.jstage.jst.go.jp/article/biomedres/28/2/28_2_79/...
[1] https://www.jstage.jst.go.jp/article/biomedres/28/2/28_2_79/...
https://www.genengnews.com/news/metabolism-and-glucose-sensi...