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Not really, no.

Cloud Run implements the Knative API, so you can actually take it away and run it on any Kubernetes cluster anywhere on a cloud or in your datacenter.

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Doesn't that require Istio and a few other things as well? I wouldn't wish Istio configuration and maintenance on anyone but the larger shops/teams. You might not be technically locked in, but not everyone can afford to dedicate the attention to tuning and maintaining Istio.

Source: at mid-sized company who has Istio in the stack.

Knative just needs a gateway (LB); not a full mesh. Istio is the default option. Alternatively you can use Gloo, Ambassador or something specifically built for Knative such as Kourier.

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