Then I'm sure you can use one of the many emulator solutions on the market to bridge the rest and if none are suitable it can't be that hard, the data is making it to the machine...
I'll happily make it happen if you need to hack something like qemu, sounds like fun.
https://stackoverflow.com/questions/41987430/what-is-the-low...
https://stackoverflow.com/questions/13831008/what-is-the-min...
PCIe parallel port: 4-8us
USB 3.0: 30us
I believe a regular PCI or even ISA parallel port can be below 1us. Those are "real" buses, unlike USB and PCIe which are more similar to packet-switched networks.
As measured on the bus.
There are also adapters for connecting PC104 to ISA.
* PC/104: ISA
* PC/104 Plus: ISA/PCI
* PCI/104: PCI
* PCI/104 Express: PCI/PCIe
* PCIe/104: PCIe
e.g. STM32H750 (< $10, Cortex-M7, 480 MHz, 1MB RAM) should easily give you room for emulating a 486.
I shudder to confirm that you are correct.
And the day one of mine truly breaks down is probably going to be the day I go looking for a new job. >D