To the best of my knowledge, it does not have mitigations against Meltdown because it assumes those protections will be implemented at the OS/firmware level, but if anyone has more experience or insight than me on that front, they're welcome to correct me.

In any case, you're making a kind of wild assumption that the type of user who disables a security feature from their OS to get a speed increase won't also likely disable security features like Site Isolation in their browser when they hear that those features increase Chrome's memory usage by somewhere between 10-20%.