Most offline systems, and many systems used only for using trusted code (which obviously bars anything with a web browser, and most internet-connected personal computing devices, among other things). Applications that equate roughly to "Scientific number-crunching" for example are
generally systems where security doesn't matter much.
There's a case to be made for gaming, and the mitigations if I remember correctly definitely ding performance on quite a few games, but because most computers used for games have significant amounts of sensitive information on them, among other things, I don't think it really holds well.
Benchmarks (I really dislike linking to this site, but given it did a bunch of benchmarks, it's not the worst thing, I guess):
'Up to 50% performance loss!' is obviously clickbait, and I disagree with a lot of the wording & conclusions & so on, but there's definitely some workloads where the trade-off makes sense.
https://www.phoronix.com/scan.php?page=article&item=linux-42...
https://www.phoronix.com/scan.php?page=article&item=linux-42...
Warning about those benchmarks, though: they're of a rather old kernel version, I imagine they tank performance less now. However, given that 5x has been performing way worse to my knowledge than 4x, 4x is probably what most people would be using for these sorts of things.
EDIT, added section below:
Ah, here we go; how it's effecting modern stuff:
https://www.phoronix.com/scan.php?page=article&item=spectre-...
The mitigations ding it a reasonable amount for a substantial amount of workloads, though it's not as intense as it used to be.