Fr4 material is basically fiberglass, and at 1.6mm thick it doesn't take much to bend it if it isn't supported. I think the weight of the motors could be an issue.
(While crashing, all bets are off. But way back when I used to fly RC gliders they had a saying "If you build them to crash, they won't fly well. If you build them to fly well, they won't crash.")
Also, it's not like anyone expects thousands of hours of flight worthiness out of a consumer or even semi-pro drone. Sure the military might spec that for their Predator replacement, but most drone hobbyists I know end up with a bunch of perfectly serviceable old drones which they no longer fly because their gear became obsolete well before the mechanics failed irrepariably.