I've tried setting up django-webpack-loader but it felt very heavy handed and I didn't like how it forces you to use some non-standard manifest plugin that was pretty buggy.
Instead I went with vanilla Webpack outputting files into Django `STATIC_ROOT`. That way Webpack is only concerned with producing the files and Django handles the whole file name hashing, compression etc in production.
I've found this to be much, much more straightforward. I'm planning to write a post about it.