Dvorak fixed my RSI problems, it is not possible that Qwerty have the same physical impact than Dvorak because physically a Qwerty typer has to "walk" a lot more distance with their fingers to type the same thing than a Dvorak typer that has all voyels on the home row.
You can spot a Dvorak user by just watching them type: their fingers walk a lot less distance than other users. It's a trick that I learned from other Dvorak users who had spotted me.
I can still touch type with Qwerty, but my hands hurt after 5 minutes.
I type around 145 wpm, including in the 3 languages I speak (all ASCII based though) and languages or frameworks that I know by hearth.
To make it easy for colleges and friends, I just have 2 aliases:
alias aoeu="setxkbmap fr"
alias qsdf="setxkbmap -I ~/.xkb code -print | xkbcomp -I$HOME/.xkb - $DISPLAY"
As you can see, the four letters of the how row, in dvorak switches to french, in french switches to dvorak. Of course it could be more complicated with more layouts if I had to support them but then I guess a systray icon would work.
Anyway, also using Kinesis Advantage 2 LF, absolutely love it, and plenty of other "non-standard" stuff like the OP says, such as a tiling window manager.
Highly recommend learning or making a better layout than Qwerty because the drawbacks are largely country balanced by the benefits IMHO.
It's not about whatever someone thinks is "standard" it's about how you want to touch the machine for the rest of your life.