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It may depend on the amount of RSI damage your hands have taken. I've played with iPads at the Apple Store, and I can't hold it comfortably for more than a few minutes.

By comparison, I can hold my 6" Sony Reader (or the Nook Color I had for a few days) indefinitely.

And, yes, I do realize that the iPad is heavy for good reason: it's got a bleeping big battery.

Where do you read though? I'd imagine that it could be too heavy if you do your reading in bed/on a recliner with the device above your face.

I read many kindle books relaxed back on my recliner, Kindle in one hand - is that easy to do with the iPad?

And if you owned a Kindle you'd know exactly what people mean. The iPad is heavy for one handed use, not to mention bulky. It does excel at PDF use though. To each his own. I prefer the Kindle for anything that is just words. Anything else is a toss up between iPad and nOok.