I'm actually gonna implement this setup (I'm looking out for used Mac minis on my local equivalent to eBay this week), for when my iPad Pro and Magic Keyboard get delivered over the next couple weeks.
This means I'll be able to use the setup for sketching and illustration, video-editing, note-taking and other typical iPad tasks, but then also be able to hook it up to the headless Mac mini (which I plan to stash in a cupboard) and use Xcode and other MacOS-only applications.
No idea how well this is gonna work, but I'm certainly looking forward to illustrating again - something I've barely done for the last few years, and which used to be a large and very satisfying part of my work (in the days before narrow specialization was such a thing).