I noticed in a couple of popular TypeScript (+React fullstack) boilerplates, that they were using ts-node to run the server in production.

Unlike babel-node, there's no mention in the documentation to avoid using it in production - but I figured there'd be performance impact, since it's transpiling on the fly (I suppose just once per require).

The catch for me is that it's probably not suitable for a sever in production as mentioned elsewhere in this thread.