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Thank you for your comment. One of the reasons we founded Sonantic was to improve accessibility so we are right there with you! We plan to do this by reducing the barriers (both financial and logistical) of voiced content for everyone from indie developers to big AAA studios. We've already begun to see progress on this through partnership with initial customers during our beta.

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I have a print-related disability causing severe convergence insufficiency with my eyes, due to a rare neurological disease affecting my peripheral nervous system.

I generally use Kurzweil 3000 (http://KurzweilEdu.com) which is made by Kurzweil Educational Systems, as a screen reader. You should definitely considering partnering with them in particular, as it would be very strategic.

Is your TTS process necessarily ahead of time, or can it be done at runtime with all the flexibility (templating, generative text etc) that brings?

That's the holy grail right there, isn't it? :) We're definitely working towards runtime but still some work to be done there to account for additional complexities and balance trade-offs re: speed, quality, accuracy etc. of the rendered output.

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