It might circle back around to being exotic again, if FPGAs take off and more work is done on highly-specialized task-specific hardware, as opposed to building the fastest general-purpose chips you can and beating problems to death with sheer speed.
Sure. The Afterburner Card that Apple is selling to accelerate ProRes decoding on the newest Mac Pro is an FPGA. They’ve opened it up to third parties like Red as well iirc.
I know Gigabyte back in the mid 2000s made a PCIE Card that let you use DDR as a disk drive once upon a time; for the original they actually used a Xilinx Spartan FPGA since it was a smaller run.
The FPGA also can have a massive unique key that allows the designer to create a whitelist algorithm that only lets certain unique IDs run that firmware. Other options involve setting a time limit for how long the firmware will run, disabling certain features, or totally bricking that FPGA forever. Spartans have this feature but it would still allow for someone to build a new design that doesn't check the device ID.
Additionally, the bitstream can be encrypted so that if a field update is necessary or the firmware is stored in a stored in a separate flash chip, someone can't reverse engineer it.
Overall, the more you pay, the more security features there are available. An example secure design would disable JTAG pins permanently and have a microprocessor inside that would handle new updates. The processor would authenticate any new encrypted firmware before programming the internal flash.
The issue with this is that FPGAs are expensive to buy as a hobbyist, expensive to buy at small quantities unless you can negotiate with Avnet or similar, and involve using software from the past if you want to program them.
Beyond FPGAs, ASICs are fairly common in very high margin/high volume electronics.
My main use for C and C++ are actually their shading language derived dialects.