(I have a turbo and TKS on my A36. Almost never need the TKS.)
Having TKS (or boots) is definitely a safety benefit in case you end up in inadvertent icing, but remember that the system can still get overwhelmed.
Avoiding icing conditions is still a good idea, even with TKS. :)
In reality most people who can afford to run a piston twin are moving down to a Cirrus or moving up to a turbine single.
Turbines give you much higher power reserves at low altitude, so they are better in icing on departure and approach, but that difference doesn't come up nearly as often as generalized maintenance issues. (Owning a 1976 piston twin was an overall negative experience. I loved the airplane, but it was a maintenance hog, mostly aging systems and aging design philosophy related.)
I agree 100% that the piston twin is a dying breed, but I think it's almost never to do with FIKI (flight-into-known-icing) issues.
That said I've heard anecdotally a 172/182 can carry ice better than a lot of other aircraft (I've only been iced up in a 172, never on a Mooney). That shouldn't matter anyways since you should avoid ice as much as possible.