I have lost count of the number of times I've seen someone lose an hour due to it. I can also count many instances of QA environments becoming inexplicably bricked by it. The correct fix for this requires opening the .py and hashing its content, at least doubling the amount of IO required to start a program. They were a great feature when parsing small files was noticeably slow, but this hasn't been true for almost 20 years.
It's therefore worth turning the question around: why do you think pyc files are useful?