Just anecdotal observation, I have been taking 40,000 IU D3, 800mcg K2, 400mg Magnesium among other things, daily for 3+ years, no issue. I had to work my way up to that. I've been reversing calcium buildup in my vascular system to lower my CaC score. I know of many people doing the same thing, some longer than I have been. We are all doing good. I also stay well hydrated.